Scale-up effects on dissolution and bioavailability of propranolol hydrochloride and metoprolol tartrate tablet formulations
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چکیده
منابع مشابه
Stability studies of expired tablets of metoprolol tartrate and propranolol hydrochloride. Part 2. Dissolution study.
The objective of the current study was to determine tablet content and perform dissolution test of expired tablets and tablets which expiry date has not exceeded. The analyzed tablets contained metoprolol tartrate (50 mg) and propranolol hydrochloride (10 mg), respectively. Content determination was performed using spectrophotometric method with UV detection; the percent of dissolved substance ...
متن کاملStability studies of expired tablets of metoprolol tartrate and propranolol hydrochloride. Part 1. Content determination.
In recent years the growing interest in drug stability problem has been observed. The stability of pharmaceutical products seems to play an important role from the economical point of view. However, there are not many studies that reported about the stability of drugs past their expiration dates. The objective of the current study was to determine tablet content of expired tablets and tablets w...
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Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...
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Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...
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mulation and in many cases the bioavailability of drug from tablets has received considerable attention. As part of the efforts to reach international harmonization of pharmaceutical excipients, the Joint Conference on Excipients identified starch as one of the top 10 excipients (1). Starch is a multipurpose excipient in tablet formulation, and it is used as a binder, disintegrant, and filler (...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2000
ISSN: 1530-9932
DOI: 10.1208/pt010214